Pomegranate Could Help People With Alzheimer’s Live Longer

Pomegranates have been linked with a lowered risk of developing Alzheimer’s disease in animal studies, but scientists now say they’ve isolated the reason why.

According to the Alzheimer’s Association, Alzheimer’s disease is the only top 10 cause of death in America that can’t be prevented, cured, or slowed down. An estimated 5.1 million people aged 65 and older suffer from the disease, and that number is expected to increase to 7.1 million by 2025.

Previous research has also touted pomegranates’ Alzheimer’s-fighting effect. A 2013 study published in the Journal of Nutrition found that pomegranate extract helped reduce the severity of Alzheimer’s disease symptoms in rodents. Research published in the journal Molecular Nutrition & Food Research in 2014 determined that punicalagin, another compound found in pomegranates, may help slow the progression of Alzheimer’s by treating brain inflammation.

Taking a cue from the ancient world

Prof. Ovadia was inspired to investigate the healing properties of cinnamon by a passage in the Bible. It describes high priests using the spice in a holy ointment, he explains, presumably meant to protect them from infectious diseases during sacrifices. After discovering that the cinnamon extract had antiviral properties, Prof. Ovadia empirically tested these properties in both laboratory and animal Alzheimer’s models.

The researchers isolated CEppt by grinding cinnamon and extracting the substance into an aqueous buffer solution. They then introduced this solution into the drinking water of mice that had been genetically altered to develop an aggressive form of Alzheimer’s disease, and fruit flies that had been mutated with a human gene that also stimulated Alzheimer’s disease and shortened their lifespan.

After four months, the researchers discovered that development of the disease had slowed remarkably and the animals’ activity levels and longevity were comparable to that of their healthy counterparts. The extract, explains Prof. Ovadia, inhibited the formation of toxic amyloid polypeptide oligomers and fibrils, which compose deposits of plaque found in the brains of Alzheimer’s patients.

In the test-tube model, the substance was also found to break up amyloid fibers, similar to those collected in the brain to kill neurons. According to Prof. Ovadia, this finding indicates that CEppt may not just fight against the development of the disease, but may help to cure it after Alzheimer’s molecules have already formed. In the future, he says, the team of researchers should work towards achieving the same result in animal models.

Adding a dash of cinnamon

Don’t rush to your spice rack just yet, however. It would take far more than a toxic level of the spice — more than 10 grams of raw cinnamon a day — to reap the therapeutic benefits. The solution to this medical catch-22, Prof. Ovadia says, would be to extract the active substance from cinnamon, separating it from the toxic elements.

“The discovery is extremely exciting. While there are companies developing synthetic AD inhibiting substances, our extract would not be a drug with side effects, but a safe, natural substance that human beings have been consuming for millennia,” says Prof. Ovadia.

Though it can’t yet be used to fight Alzheimer’s, cinnamon still has its therapeutic benefits — it can also help prevent viral infections when sprinkled into your morning tea.

Pomegranate Could Help People With Alzheimer’s Live Longer


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Materials provided by American Friends of Tel Aviv Universit

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